18-P001 Glypicans enhance robustness in Hedgehog gradient formation
نویسندگان
چکیده
منابع مشابه
18-P001 Glypicans enhance robustness in Hedgehog gradient formation
The secreted protein Hedgehog (Hh) acts a morphogen, forming a concentration gradient and controlling cell fate decisions in various developmental stages in many animals. In recent years, there has been significant interest in the role that glypicans play in Hh gradient formation and signalling; with various experimental studies demonstrating an effect on Hh transport, Hh stability and downstre...
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Spatial gradients of Hedgehog signalling play a central role in many patterning events during animal development, regulating cell fate determination and tissue growth in a variety of tissues and developmental stages. Experimental evidence suggests that many of the proteins responsible for regulating Hedgehog signalling and transport are themselves targets of Hedgehog signalling, leading to mult...
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Large bone defects naturally regenerate via a highly vascularized tissue which progressively remodels into cartilage and bone. Current approaches in bone tissue engineering are restricted by delayed vascularization and fail to recapitulate this stepwise differentiation toward bone tissue. Here, we use the morphogen Sonic Hedgehog (Shh) to induce the in vitro organization of an endothelial capil...
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The secreted protein Hedgehog (Hh) acts a morphogen, forming a concentration gradient and controlling cell fate decisions in various developmental stages in many animals. In recent years, there has been significant interest in the role that glypicans play in Hh gradient formation and signalling; with various experimental studies demonstrating an effect on Hh transport, Hh stability and downstre...
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Members of the Hedgehog (Hh) family of proteins are conserved morphogens that modulate cell fates in target tissues in different developmental systems. Dysregulation of Hh signaling results in a wide range of human diseases. The mature Hh is modified by lipids in two places, with palmitate at the N-terminus and cholesterol at the C-terminus. The lipid modifications are essential to the proper s...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.769